DEPRESSION OF HYPOXIC PULMONARY VASOCONSTRICTION BY SODIUM NITROPRUSSIDE AND NITROGLYCERINE
نویسندگان
چکیده
منابع مشابه
Depression of hypoxic pulmonary vasoconstriction by sodium nitroprusside and nitroglycerine.
The pulmonary vasoconstrictor response to the unilateral administration of 7% oxygen was studied in 10 anaesthetized dogs in which the lungs were mechanically ventilated. The distribution of blood flow between the two lungs was measured continuously by recording the radioactivity in the mixed expired gas from each lung during the infusion i.v. of xenon-133. Infusions of nitroglycerine and sodiu...
متن کاملHypoxic pulmonary vasoconstriction.
Humans encounter hypoxia throughout their lives. This occurs by destiny in utero, through disease, and by desire, in our quest for altitude. Hypoxic pulmonary vasoconstriction (HPV) is a widely conserved, homeostatic, vasomotor response of resistance pulmonary arteries to alveolar hypoxia. HPV mediates ventilation-perfusion matching and, by reducing shunt fraction, optimizes systemic Po(2). HPV...
متن کاملHypoxic pulmonary vasoconstriction.
Hypoxic pulmonary vasoconstriction is a local reflex in the lung that diverts blood away from poorly oxygenated regions. Improvements in understanding of modulators of this response have led to pharmacologic methods whereby V/Q matching may potentially be improved in certain types of pulmonary pathology and during anesthesia for thoracic surgical procedures.
متن کاملHypoxic pulmonary vasoconstriction: clinical implications.
Fetal origin of HPV HPV originates in the fetus [3]. Vasomotor tone can be detected in the human fetal pulmonary circulation in the last trimester of pregnancy [4]. HPV contributes significantly to the high pulmonary vascular resistance (PVR) in the fetus (only 10–15% of right ventricular outflow goes to the lungs) [5], mainly because pulmonary artery and alveolar fluid oxygen tension (PO2) lev...
متن کاملDepression of hypoxic pulmonary vasoconstriction in the dog by dopamine and isoprenaline.
The effects of dopamine and isoprenaline on the pulmonary vasoconstrictor response to alveolar hypoxia were assessed by measuring the redistribution of blood flow between the lungs in response to unilateral hypoxia. Dose rates of dopamine 25 micrograms kg-1 min-1 and isoprenaline 0.25 micrograms kg-1 min-1 (which produced equal increments in thecontractile force of the heart in dogs) produced a...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1981
ISSN: 0007-0912
DOI: 10.1093/bja/53.1.11